A multicentre randomized pilot trial on the effectiveness of different levels of cooling in comatose survivors of out-of-hospital cardiac arrest: the FROST-I trial

Author:

Lopez-de-Sa EstebanORCID,Juarez Miriam,Armada Eduardo,Sanchez-Salado José C.,Sanchez Pedro L.,Loma-Osorio Pablo,Sionis Alessandro,Monedero Maria C.,Martinez-Sellés Manuel,Martín-Benitez Juán C.,Ariza Albert,Uribarri Aitor,Garcia-Acuña José M.,Villa Patricia,Perez Pablo J.,Storm Christian,Dee Anne,Lopez-Sendon Jose L.

Funder

ZOLL Medical Corporation

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

Reference22 articles.

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2. Castrejon S, Cortes M, Salto ML, Benittez LC, Rubio R, Juarez M, Lopez de Sa E, Bueno H, Sanchez PL, Fernandez Aviles F (2009) Improved prognosis after using mild hypothermia to treat cardiorespiratory arrest due to a cardiac cause: comparison with a control group. Rev Esp Cardiol 62:733–741

3. Stub D, Schmicker RH, Anderson ML, Callaway CW, Daya MR, Sayre MR, Elmer J, Grunau BE, Aufderheide TP, Lin S, Buick JE, Zive D, Peterson ED, Nichol G, ROC Investigators (2015) Association between hospital post-resuscitative performance and clinical outcomes after out-of-hospital cardiac arrest. Resuscitation 92:45–52

4. Lopez-de-Sa E, Rey JR, Armada E, Salinas P, Viana-Tejedor A, Espinosa-Garcia S, Martinez-Moreno M, Corral E, Lopez-Sendon J (2012) Hypothermia in comatose survivors from out-of-hospital cardiac arrest: pilot trial comparing two levels of target temperature. Circulation 126:2826–2833

5. Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Aneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Kober L, Langorgen J, Lilja G, Moller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, TTM Trial Investigators (2013) Targeted temperature management at 33 °C versus 36 °C after cardiac arrest. N Engl J Med 369:2197–2206

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