Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial-Reference-Cited by-同舟云学术

Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial

Published:2021-10-04 Issue:11 Volume:47 Page:1284-1294
ISSN:0342-4642
Container-title:Intensive Care Medicine
language:en
Short-container-title:Intensive Care Med

Author:

Laterre Pierre-François,Pickkers Peter,Marx Gernot,Wittebole Xavier,Meziani Ferhat,Dugernier Thierry,Huberlant Vincent,Schuerholz Tobias,François Bruno,Lascarrou Jean-Baptiste,Beishuizen Albertus,Oueslati Haikel,Contou Damien,Hoiting Oscar,Lacherade Jean-Claude,Chousterman Benjamin,Pottecher Julien,Bauer Michael,Godet Thomas,Karakas Mahir,Helms Julie,Bergmann Andreas,Zimmermann Jens,Richter Kathleen,Hartmann Oliver,Pars Melanie,Mebazaa Alexandre^ORCID,Castanares Diego,Collienne Christine,Gèrards Ludovic,Hantson Phillipe,Montiel Virginie,Berghe Caroline,Dujardin Marie-France,Gielens Leslie,Renard Suzanne,Jorens Philippe,Asfar Pierre,Plantefève Gaëtan,Duranteau Jacques,Weiss Emmanuel,Vuillard Constance,Fedou Anne-Laure,Goudelin Marine,Evrard Bruno,Daix Thomas,Desachy Arnaud,Vignon Philippe,Duchambon Anne-Aurore,Baudrillart Ludmila,Bourzeix Paul,Gay Alexandra,Prevost Céline,Chalot Coralie,Herafa Isabelle,Engels Perrine,Maëlle Martin,Abeud Lila-Fariza,Berton Laure,Cerlinskaite Kamile,Deye Nicolas,Fournier Marie-Celine,Hadjam Tassadit,Hollinger Alexa,Javanainen Tuija,Jourdaine Clement,Legrand Matthieu,Louadah Badr,Neuschwander Arthur,Clere-Jehl Raphaël,Demiselle Julien,Merdji Hamid,Monnier Alexandra,Mercier Emmanuelle,Kluge Stefan,Zarbock Alexander,van Zanten Arthur R. H.,Vermeijden Wytze,Dormans Tom,

Funder

Adrenomed AG

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00134-021-06537-5.pdf

Reference19 articles.

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8):801–810

2. Lee WL, Slutsky AS (2010) Sepsis and endothelial permeability. N Engl J Med 363(7):689–691

3. Karpinich NO, Hoopes SL, Kechele DO, Lenhart PM, Caron KM (2011) Adrenomedullin function in vascular endothelial cells: insights from genetic mouse models. Curr Hypertens Rev 7(4):228–239