Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial
Author:
Funder
Jeffrey and Judy Buzen
Publisher
Springer Science and Business Media LLC
Subject
Critical Care and Intensive Care Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00134-020-06216-x.pdf
Reference29 articles.
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2. Lambden S, Creagh-Brown BC, Hunt J, Summers C, Forni LG (2018) Definitions and pathophysiology of vasoplegic shock. Crit Care 22(1):174. https://doi.org/10.1186/s13054-018-2102-1
3. Dhruva SS, Redberg RF (2010) Accelerated approval and possible withdrawal of midodrine. JAMA 304(19):2172–2173. https://doi.org/10.1001/jama.2010.1695
4. Mitka M (2012) Trials to address efficacy of midodrine 18 years after it gains FDA approval. JAMA 307(11):1124–1127. https://doi.org/10.1001/jama.2012.291
5. Smith W, Wan H, Much D, Robinson AG, Martin P (2016) Clinical benefit of midodrine hydrochloride in symptomatic orthostatic hypotension: a phase 4, double-blind, placebo-controlled, randomized, tilt-table study. Clin Auton Res 26(4):269–277. https://doi.org/10.1007/s10286-016-0363-9
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