Tackling sepsis-associated AKI: are there any chances of REVIVAL with new approaches?

Author:

Prowle John R.ORCID,Bagshaw Sean M.,Forni Lui G.

Publisher

Springer Science and Business Media LLC

Reference7 articles.

1. Zarbock A, Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, Kashani K, Koyner JL, Pannu N, Meersch M, Reis T, Rimmele T, Bagshaw SM, Bellomo R, Cantaluppi V, Deep A, De Rosa S, Perez-Fernandez X, Husain-Syed F, Kane-Gill SL, Kelly Y, Mehta RL, Murray PT, Ostermann M, Prowle J, Ricci Z, See EJ, Schneider A, Soranno DE, Tolwani A, Villa G, Ronco C, Forni LG (2023) Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative Workgroup. Nat Rev Nephrol 19:401–417

2. Pickkers P, Angus DC, Bass K, Bellomo R, van den Berg E, Bernholz J, Bestle MH, Doi K, Doig CJ, Ferrer R, Francois B, Gammelager H, Goettrup Pedersen U, Hoste E, Iversen S, Joannidis M, Kellum JA, Liu K, Meersch M, Mehta R, Millington S, Murray PT, Nichol A, Ostermann M, Pettilä V, Solling C, Winkel M, Young PJ, and Zarbock A on behalf of the REVIVAL investigators (2023) Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL). Int Care Med. https://doi.org/10.1007/s00134-023-07271-w

3. Peters E, Geraci S, Heemskerk S, Wilmer M, Bilos A, Kraenzlin B, Gretz N, Pickkers P, Masereeuw R (2015) Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. Br J Pharmacol 172:4932–4945

4. Heemskerk S, Masereeuw R, Moesker O, Bouw MP, Van Der Hoeven JG, Peters WH, Russel FG, Pickkers P, AS Group (2009) Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med 37:417-E411

5. Pickkers P, Mehta RL, Murray PT, Joannidis M, Molitoris BA, Kellum JA, Bachler M, Hoste EAJ, Hoiting O, Krell K, Ostermann M, Rozendaal W, Valkonen M, Brealey D, Beishuizen A, Meziani F, Murugan R, De Geus H, Payen D, Van Den Berg E, Arend J, Investigators FTS-A (2018) Effect of human recombinant alkaline phosphatase on 7-day creatinine clearance in patients with sepsis-associated acute kidney injury: a randomized clinical trial. JAMA 320:1998–2009

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