Severity of hypoxemia may explain indeterminate results in pediatric trials of inhaled nitric oxide
Author:
Funder
National Heart, Lung, and Blood Institute
Publisher
Springer Science and Business Media LLC
Subject
Critical Care and Intensive Care Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00134-021-06434-x.pdf
Reference6 articles.
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2. Bronicki RA, Fortenberry J, Schreiber M, Checchia PA, Anas NG (2015) Multicenter randomized controlled trial of inhaled nitric oxide for pediatric acute respiratory distress syndrome. J Pediatrics 166:365 e361-369 e361
3. Taylor RW, Zimmerman JL, Dellinger RP, Straube RC, Criner GJ, Davis K Jr, Kelly KM, Smith TC, Small RJ, Inhaled Nitric Oxide in AS (2004) Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA 291:1603–1609
4. Yehya N, Harhay MO, Klein MJ, Shein SL, Pineres-Olave BE, Izquierdo L, Sapru A, Emeriaud G, Spinella PC, Flori HR, Dahmer MK, Maddux AB, Lopez-Fernandez YM, Haileselassie B, Hsing DD, Chima RS, Hassinger AB, Valentine SL, Rowan CM, Kneyber MCJ, Smith LS, Khemani RG, Thomas NJ, Pediatric Acute Respiratory Distress Syndrome I, Epidemiology VI, the Pediatric Acute Lung I, Sepsis Investigators N (2020) Predicting mortality in children with pediatric acute respiratory distress syndrome: a pediatric acute respiratory distress syndrome incidence and epidemiology study. Crit Care Med 48:e514–e522
5. Harhay MO, Casey JD, Clement M, Collins SP, Gayat E, Gong MN, Jaber S, Laterre PF, Marshall JC, Matthay MA, Monroe RE, Rice TW, Rubin E, Self WH, Mebazaa A (2020) Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop. Intensive Care Med 46:930–942
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