Antimicrobial de-escalation as part of antimicrobial stewardship in intensive care: no simple answers to simple questions—a viewpoint of experts

Author:

De Waele Jan J.ORCID,Schouten JeroenORCID,Beovic BojanaORCID,Tabah AlexisORCID,Leone MarcORCID

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

Reference41 articles.

1. Tabah A, Cotta MO, Garnacho-Montero J, Schouten J, Roberts JA, Lipman J, Tacey M, Timsit JF, Leone M, Zahar JR, De Waele JJ (2016) A systematic review of the definitions, determinants, and clinical outcomes of antimicrobial de-escalation in the intensive care unit. Clin Infect Dis 62:1009–1017. https://doi.org/10.1093/cid/civ1199

2. Tabah A, Bassetti M, Kollef MH, Zahar JR, Paiva JA, Timsit JF, Roberts J, Schouten J, Giamarellou H, Rello J, De Waele J, Shorr A, Leone M, Poulakou G, Depuydt P, Garnacho-Montero J (2019) Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP). Intensive Care Med. https://doi.org/10.1007/s00134-019-05866-w

3. Rello J, Paiva JA, Baraibar J, Barcenilla F, Bodi M, Castander D, Correa H, Diaz E, Garnacho J, Llorio M, Rios M, Rodriguez A, Solé-Violán J (2001) International conference for the development of consensus on the diagnosis and treatment of ventilator-associated pneumonia. Chest 120:955–970. https://doi.org/10.1378/chest.120.3.955

4. De Waele JJ, Akova M, Antonelli M, Canton R, Carlet J, De Backer D, Dimopoulos G, Garnacho-Montero J, Kesecioglu J, Lipman J, Mer M, Paiva JA, Poljak M, Roberts JA, Rodriguez Bano J, Timsit JF, Zahar JR, Bassetti M (2018) Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance. Intensive Care Med 44:189–196. https://doi.org/10.1007/s00134-017-5036-1

5. Mathieu C, Pastene B, Cassir N, Martin-Loeches I, Leone M (2019) Efficacy and safety of antimicrobial de-escalation as a clinical strategy. Expert Rev Anti Infect Ther 17:79–88. https://doi.org/10.1080/14787210.2019.1561275

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