Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxinN-methyl-4-phenylpyridinium (MMP+) towards cultured dopaminergic neuroblastoma cells

Author:

Fang J.,Zuo D.,Yu P. H.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference35 articles.

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3. Baldessarini RJ (1985) Drugs and the treatment of psychiatric disorders. In: Gilman GA, Goodman LS, Rall TW, Murad F (eds) Goodman and Gilman's pharmacological basis of therapeutics, 7th edn. Macmillan, New York, pp 385–445

4. Bloomquist J, King E, Wright A, Mytilineou C, Kimura K, Catagnoli K, Castagoli N Jr (1994) 1-Methyl-4-phenylpyridinium-like neurotoxicity of pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies. J Pharmacol Exp Ther 270:822–830

5. DiPasquale B, Marini AM, Youle RJ (1991) Apoptosis and DNA degradation induced byN-methyl-4-phenylpyridinium in neurons. Biochem Biophy Res Commun 181:1442–1448

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