Renaissance of Aspirin for the Primary and Secondary Prevention of Venous Thromboembolism
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s40138-013-0025-3.pdf
Reference70 articles.
1. Heit J, Cohen A, Anderson Jr F. Estimated annual number of incident and recurrent, non-fatal and fatal venous thromboembolism (VTE) events in the US. Blood (ASH Annu Meet Abstr). 2005;106(abstract #910).
2. •• Anderson DR, Dunbar MJ, Bohm ER, Belzile E, Kahn SR, Zukor D, et al. Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial. Ann Intern Med. 2013;158(11):800–6. This study is pivotal in that it is the first well-designed, randomized prospective trial to directly compare LMWH versus aspirin for THR.
3. •• Brighton TA, Eikelboom JW, Mann K, Mister R, Gallus A, Ockelford P, et al. Low-dose aspirin for preventing recurrent venous thromboembolism. N Engl J Med. 2012;367(21):1979–87. This is the WARFASA trial that compares aspirin to placebo after an initial heparin/warfarin trial to assess rates of recurrent VTE.
4. •• Becattini C, Agnelli G, Schenone A, Eichinger S, Bucherini E, Silingardi M, et al. Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med. 2012;366(21):1959–67. This is the ASPIRE trial that compares aspirin to placebo after an initial heparin/warfarin trial to assess rates of recurrent VTE. Pivotal design and important because recurrent VTE rates were significantly reduced in the primary trial alone.
5. Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, et al. Perioperative management of antithrombotic therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141(2 Suppl):e326S–50S.
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