Large Vessel Occlusion Stroke Detection in the Prehospital Environment

Author:

Patrick LaurenORCID,Smith Wade,Keenan Kevin J.

Abstract

Abstract Purpose of Review Endovascular therapy for acute ischemic stroke secondary to large vessel occlusion (LVO) is time-dependent. Prehospital patients with suspected LVO stroke should be triaged directly to specialized stroke centers for endovascular therapy. This review describes advances in LVO detection among prehospital suspected stroke patients. Recent Findings Clinical prehospital stroke severity tools have been validated in the prehospital setting. Devices including EEG, SSEPs, TCD, cranial accelerometry, and volumetric impedance phase-shift-spectroscopy have recently published data regarding LVO detection in hospital settings. Mobile stroke units bring thrombolysis and vessel imaging to patients. Summary The use of a prehospital stroke severity tool for LVO triage is now widely supported. Ease of use should be prioritized as there are no meaningful differences in diagnostic performance amongst tools. LVO diagnostic devices are promising, but none have been validated in the prehospital setting. Mobile stroke units improve patient outcomes and cost-effectiveness analyses are underway.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Reference66 articles.

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3. • Albers GW, Marks MP, Kemp S, Christensen S, Tsai JP, Ortega-Gutierrez S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378(8):708–18. https://doi.org/10.1056/NEJMoa1713973DEFUSE3 trial: This seminal paper demonstrated safety of late-window thrombectomy and improved functional outcomes for patients with proximal large vessel occlusions presenting within 6-16 hours of last known well time with the use of perfusion imaging. Historically, perfusion imaging is not required for evaluation of patients with large vessel occlusion presenting within 6 hours of their last known well time. This paper has changed clinical practice, in that hospitals can now use perfusion imaging to detect mismatch between ischemic tissue at risk and infarcted tissue in patients presenting outside of the standard thrombectomy window. As such, this practice change has allowed us to safely and effectively treat innumerable additional patients with delayed presentation of strokes caused by large vessel occlusions.

4. Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372(11):1019–30. https://doi.org/10.1056/NEJMoa1414905.

5. • Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378(1):11–21. https://doi.org/10.1056/NEJMoa1706442DAWN trial: Similar to the results of the DEFUSE3 trial, this seminal trial demonstrated improved functional outcomes for thrombectomy in patients with proximal large vessel occlusion presenting within 6-24 hours of last known well time with the use of mismatch between clinical deficit and infarct.

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