Rationale for Upstream Dual Antiplatelet Therapy in Non-ST-Segment Elevation Myocardial Infarction

Author:

Pollack Charles V.,Amin Alpesh,Villanueva Tomas,Peacock Frank,Summers Richard,Davatelis George,Kaatz Scott

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Reference38 articles.

1. •• Diercks DB, Kontos MC, Hollander JE, et al. ED administration of thienopyridines in non-ST-segment elevation myocardial infarction: results from the NCDR. Am J Emerg Med. 2013;31:1005–11. This paper provides a reasonable (if underpowered) validation of the upstream dual antiplatelet therapy approach.

2. •• Pollack CV, Amin A, Talan DA. Emergency medicine and hospital medicine: a call for collaboration. Am J Med. 2012;125:826.e1–6. This paper provides the rationale for closer and ongoing collaboration among emergency physicians and hospitalists in the management of acute coronary syndrome and other diagnoses.

3. • Anderson JL, Adams CD, Antman EM, et al. 2011 ACCF/AHA focused update incorporated into the 2007 ACC/AHA guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;123:e426–579. These are the most recent US Guidelines for NSTE-ACS evaluation and management.

4. Yusuf S, Mehta SR, Zhao F, et al. Early and late effects of clopidogrel in patients with acute coronary syndromes. Circulation. 2003;107:966–72.

5. • Bellemain-Appaix A, O’Connor SA, Silvain J, et al. Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis. JAMA. 2012;3083:2507–16. This meta-analysis evaluates the upstream use of clopidogrel in clinical trials.

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