Author:
Said Oliver,Schock Justus,Krämer Nils,Thüring Johannes,Hitpass Lea,Schad Philipp,Kuhl Christiane,Abrar Daniel,Truhn Daniel,Nebelung Sven
Abstract
Abstract
Objective
Beyond static assessment, functional techniques are increasingly applied in magnetic resonance imaging (MRI) studies. Stress MRI techniques bring together MRI and mechanical loading to study knee joint and tissue functionality, yet prototypical axial compressive loading devices are bulky and complex to operate. This study aimed to design and validate an MRI-compatible pressure-controlled varus–valgus loading device that applies loading along the joint line.
Methods
Following the device’s thorough validation, we demonstrated proof of concept by subjecting a structurally intact human cadaveric knee joint to serial imaging in unloaded and loaded configurations, i.e. to varus and valgus loading at 7.5 kPa (= 73.5 N), 15 kPa (= 147.1 N), and 22.5 kPa (= 220.6 N). Following clinical standard (PDw fs) and high-resolution 3D water-selective cartilage (WATSc) sequences, we performed manual segmentations and computations of morphometric cartilage measures. We used CT and radiography (to quantify joint space widths) and histology and biomechanics (to assess tissue quality) as references.
Results
We found (sub)regional decreases in cartilage volume, thickness, and mean joint space widths reflective of areal pressurization of the medial and lateral femorotibial compartments.
Discussion
Once substantiated by larger sample sizes, varus–valgus loading may provide a powerful alternative stress MRI technique.
Funder
START Programme of the University Hospital Aachen
Deutsche Forschungsgemeinschaft
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology,Biophysics
Reference55 articles.
1. Gold GE, Besier TF, Draper CE, Asakawa DS, Delp SL, Beaupre GS (2004) Weight-bearing MRI of patellofemoral joint cartilage contact area. J Magn Reson Imaging JMRI 20(3):526–530
2. Buchan LL, Zhang H, Konan S, Heaslip I, Ratzlaff CR, Wilson DR (2016) Open-MRI measures of cam intrusion for hips in an anterior impingement position relate to acetabular contact force. J Orthop Res 34(2):205–216
3. Shapiro LM, Gold GE (2012) MRI of weight bearing and movement. Osteoarthr Cartil 20(2):69–78
4. Chung M, Dahabreh IJ, Hadar N, Ratichek SJ, Gaylor JM, Trikalinos TA, Lau J (2011) Emerging MRI technologies for imaging musculoskeletal disorders under loading stress. AHRQ comparative effectiveness technical briefs, No. 7. Agency for Healthcare Research and Quality (US), Rockville (MD)
5. Subburaj K, Souza RB, Stehling C, Wyman BT, Le Graverand-Gastineau MP, Link TM, Li X, Majumdar S (2012) Association of MR relaxation and cartilage deformation in knee osteoarthritis. J Orthop Res 30(6):919–926
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