Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cells

Author:

Abuharbeid Shaker,Apel J�rgen,Zugmaier Gerhard,Knabbe Cornelius,Sander Martin,Gilbert Sandra,Czubayko Frank,Aigner Achim

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference33 articles.

1. Aigner A, Hsieh SS, Malerczyk C, Czubayko F (2000) Reversal of HER-2 over-expression renders human ovarian cancer cells highly resistant to taxol. Toxicology 144:221?228

2. Alaoui-Jamali MA, Paterson J, Al Moustafa AE, Yen L (1997) The role of ErbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: mechanisms and implications. Biochem Cell Biol 75:315?325

3. Baasner S, von Melchner H, Klenner T, Hilgard P, Beckers T (1996) Reversible tumorigenesis in mice by conditional expression of the HER2/c-erbB2 receptor tyrosine kinase. Oncogene 13:901?911

4. Baselga J, Norton L, Albanell J, Kim YM, Mendelsohn J (1998) Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res 58:2825?2831

5. Berchuck A, Kamel A, Whitaker R, Kerns B, Olt G, Kinney R, Soper JT, Dodge R, Clarke-Pearson DL, Marks P et al (1990) Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 50:4087?4091

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