Protective effect of nerolidol-loaded in nanospheres against cerebral damage caused by Trypanosoma evansi

Author:

Baldissera Matheus D.ORCID,Souza Carine F.,Riéffel Roberta C.,Velho Maiara C.,Ramos Andiara P.,Nascimento Kátia,Sagrillo Michele R.,Ourique Aline F.,da Silva Aleksandro S.,Stefani Lenita M.,Monteiro Silvia G.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference24 articles.

1. Baldissera MD, Sagrillo MR, de Sá MF, Peroza LR, Posser CP, de Brum GF, Peres DS, De Mello ALB, Ferrão M, Souza CF, da Silva AS, Monteiro SG (2016a) Increased in cyclooxygenase-2 immunoreactivity and DNA damage of rats infected by Trypanosoma evansi. Comp Clin Pathol 25:585–591

2. Baldissera MD, Grando TH, Souza CF, Cossetin LF, Sagrillo MR, Nascimento K, da Silva AS, Dalla Lana DF, Da Silva AS, Stefani LM, Monteiro SG (2016b) Nerolidol nanospheres increases its trypanocidal efficacy against Trypanosoma evansi: new approach against diminazene aceturate resistance and toxicity. Exp Parasitol 166:144–149

3. Baldissera MD, Souza CF, Grando TH, Moreira KLS, Schafer AS, Cossetin LF, da Silva AS, da Veiga ML, da Rocha MIUM, Stefani LM, da Silva AS, Monteiro SG (2017a) Nerolidol-loaded nanospheres prevent behavioral impairment via ameliorating Na+, K+-ATPase and AChE activities as well as reducing oxidative stress in the brain of Trypanosoma evansi-infected mice. Naunyn Schmiedeberg's Arch Pharmacol 390:139–148

4. Baldissera MD, Souza CF, Boligon AA, Grando TH, De Sá MF, Da Silva AS, Stefani LM, Baldisserotto B, Monteiro SG (2017b) Solving the challenge of the blood-brain-barrier to treat infections caused by Trypanosoma evansi: evaluation of nerolidol-loaded nanospheres in mice. Parasitology 144:1543–1550

5. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254

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