Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel kappa opioid receptor agonist ZYKR1: a randomized double-blind placebo-control phase 1 study in healthy adult human participants
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00210-023-02912-9.pdf
Reference19 articles.
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2. Aldrich JV, McLaughlin JP (2009) Peptide kappa opioid receptor ligands: potential for drug development. AAPS J. 11(2):312–22. https://doi.org/10.1208/s12248-009-9105-4
3. Bart G, Schluger JH, Borg L, Ho A, Bidlack JM, Kreek MJ (2005) Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity? Neuropsychopharmacology 30(12):2254–2262. https://doi.org/10.1038/sj.npp.1300811
4. Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE, Vallejo R (2008) Opioid complications and side effects. Pain Physician 11(2 Suppl):S105–S120
5. Butelman ER, Kreek MJ (2001) Kappa-opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists. Eur J Pharmacol 423(2–3):243–249. https://doi.org/10.1016/s0014-2999(01)01121-9
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