Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway-Reference-Cited by-同舟云学术

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Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway

Published:2020-01-06 Issue:5 Volume:393 Page:897-908
ISSN:0028-1298
Container-title:Naunyn-Schmiedeberg's Archives of Pharmacology
language:en
Short-container-title:Naunyn-Schmiedeberg's Arch Pharmacol

Author:

Abo-El Fetoh Mohammed E.,Helal Gouda K.,Saleh I. G.,Ewees M.,ElShafey Mohamed,Elnagar Mohamed R.,Akool El-Sayed

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00210-019-01798-w.pdf

Reference44 articles.

1. Akool E-S (2015) Molecular mechanisms of the protective role of wheat germ oil against cyclosporin A-induced hepatotoxicity in rats. Pharm Biol 53:1311–1317

2. Akool El-S, Doller A, Babelova A, Tsalastra W, Moret K, Schaefer L, Pfeilschifter J, Eberhardt W (2008) Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J Immunol 181:2831–2845

3. Akool E-S, Gauer S, Osman B, Doller A, Schulz S, Geiger H, Pfeilschifter J, Eberhardt W (2012) Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling. Biochem Pharmacol 83:286–295

4. Alnajjar AM, Elsiesy HA (2015) Natural products and hepatocellular carcinoma: review. Hepatoma Res 1:119–124

5. Balah A, Ezzat O, Akool E-S (2018) Vitamin E inhibits cyclosporin A-induced CTGF and TIMP-1 expression by repressing ROS-mediated activation of TGF-β/Smad signaling pathway in rat liver. Int Immunopharmacol 65:493–502

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