Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M2 KO animals
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00210-012-0800-9.pdf
Reference46 articles.
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2. Benes J, Novakova M, Rotkova J, Farar V, Kvetnansky R, Riljak V, Myslivecek J (2012) Beta3 adrenoceptors substitute the role of M2 muscarinic receptor in coping with cold stress in the heart: evidence from M2KO mice. Cell Mol Neurobiol 32:589–869
3. Boknik P, Grote-Wessels S, Barteska G, Jiang M, Müller FU, Schmitz W, Neumann J, Birnbaumer L (2009) Genetic disruption of G proteins, Gi2α or Goα, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium. Br J Pharmacol 158:1557–1564
4. Brodde OE (2008) Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses. Pharmacol Ther 117:1–29
5. Brodde OE, Leineweber K (2004) Autonomic receptor systems in the failing and aging human heart: similarities and differences. Eur J Pharmacol 500:167–176
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