Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways

Author:

Li Liu,Ji Yi,Fan Junting,Li Furong,Li Yan,Wu Mianhua,Cheng Haibo,Xu Changliang

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference54 articles.

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3. Bai JP, Shi YL, Fang X, Shi QX (2003) Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. Eur J Pharmacol 464:9–15

4. Bai WD, Ye XM, Zhang MY, Zhu HY, Xi WJ, Huang X, Zhao J, Gu B, Zheng GX, Yang AG, Jia LT (2014) MiR-200c suppresses TGF-beta signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer. Int J Cancer 135:1356–1368

5. Baquero P, Jimenez-Mora E, Santos A, Lasa M, Chiloeches A (2015) TGFbeta induces epithelial-mesenchymal transition of thyroid cancer cells by both the BRAF/MEK/ERK and Src/FAK pathways. Mol Carcinog 55(11):1639–1654

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