Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15-Reference-Cited by-同舟云学术

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15

Published:2008-06-13 Issue:5 Volume:378 Page:515-528
ISSN:0028-1298
Container-title:Naunyn-Schmiedeberg's Archives of Pharmacology
language:en
Short-container-title:Naunyn-Schmied Arch Pharmacol

Author:

Kiss Béla,Laszlovszky István,Horváth Attila,Némethy Zsolt,Schmidt Éva,Bugovics Gyula,Fazekas Károly,Gyertyán István,Ágai-Csongor Éva,Domány György,Szombathelyi Zsolt

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00210-008-0308-5.pdf

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2. Blagg J, Allerton CMN, Batchelor DVJ, Baxter AB, Burring DJ, Carr AS, Nichols CL, Phipps J, Sanderson VG, Verrier H, Wong S (2007) Design and synthesis of functionally selective D3 agonist and its in vivo delivery via intranasal route. Biorg Med Chem Lett 17:6691–6696

3. Carlsson A, Davis JN, Kehr W, Linqduist M, Atack CV (1972) Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn-Schmiedeberg’s Arch Pharmacol 275:153–168

4. Castelli MP, Mocci I, Sanna AM, Gessa GL, Pani L (2001) (-)S amisulpride bind with high affinity to cloned dopamine D3 and D2 receptors. Eur J Pharmacol 432:143–147

5. Cheng YC, Prusoff WH (1973) Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 percent inhibition (IC50) of an enzymatic reaction. Biochem Pharmacol 22:3099–3108

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