Inhibition of Pyruvate kinase M2 (PKM2) by shikonin attenuates isoproterenol-induced acute myocardial infarction via reduction in inflammation, hypoxia, apoptosis, and fibrosis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00210-023-02593-4.pdf
Reference56 articles.
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2. Abdelzaher WY, Ahmed SM, Welson NN et al (2021) Dapsone Ameliorates Isoproterenol-Induced Myocardial Infarction via Nrf2/ HO-1; TLR4/ TNF-α Signaling Pathways and the Suppression of Oxidative Stress, Inflammation, and Apoptosis in Rats. Front Pharmacol 12:669679. https://doi.org/10.3389/fphar.2021.669679
3. Boarescu PM, Chirilă I, Bulboacă AE et al (2019) Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction. Oxid Med Cell Longev 2019:7847142. https://doi.org/10.1155/2019/7847142
4. Chen J, Xie J, Jiang Z et al (2011) Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene 30:4297–4306. https://doi.org/10.1038/onc.2011.137
5. Clower CV, Chatterjee D, Wang Z et al (2010) The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci 107:1894–1899. https://doi.org/10.1073/pnas.0914845107
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