Author:
Levy Finn Olav,Osnes Jan-Bjørn
Abstract
AbstractDespite the proven effects of statins in preventing cardiovascular disease, their diabetogenic effect has caused concern. The mechanism of this diabetogenic effect is unknown. We suggest a novel mechanism that may contribute to the diabetogenic effect of statins, through an effect of statins that has apparently escaped previous consideration. Briefly, by inhibiting HMG-CoA reductase, statins may cause accumulation of acetate, which through FFA2 and FFA3 stimulation may inhibit insulin secretion.
Funder
South-Eastern Norway Regional Health Authority
Research Council of Norway
Norwegian Health Association
Anders Jahre Foundation for the Promotion of Science
Family Blix Foundation
University of Oslo
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine