Empagliflozin reduces endoplasmic reticulum stress associated TXNIP/NLRP3 activation in tunicamycin-stimulated aortic endothelial cells
Author:
Funder
Natural Sciences and Engineering Research Council of Canada
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00210-023-02607-1.pdf
Reference68 articles.
1. Abdollahi E, Keyhanfar F, Delbandi AA, Falak R, Hajimiresmaiel SJ, Shafiei M (2022) Dapagliflozin exerts anti-inflammatory effects via inhibition of LPS-induced TLR-4 overexpression and NF-kappaB activation in human endothelial cells and differentiated macrophages. Eur J Pharmacol 918:174715. https://doi.org/10.1016/j.ejphar.2021.174715
2. Andreadou I, Efentakis P, Balafas E, Togliatto G, Davos CH, Varela A, Dimitriou CA, Nikolaou P-E, Maratou E, Lambadiari V, Ikonomidis I, Kostomitsopoulos N, Brizzi MF, Dimitriadis G, Iliodromitis EK (2017) Empagliflozin limits myocardial infarction in vivo and cell death in vitro: role of STAT3, mitochondria, and redox aspects. Front Physiol 8:1077–1077. https://doi.org/10.3389/fphys.2017.01077
3. Bai B, Yang Y, Wang Q, Li M, Tian C, Liu Y, Aung LHH, Li P-f, Yu T, Chu X-m (2020) NLRP3 inflammasome in endothelial dysfunction. Cell Death Dis 11:776. https://doi.org/10.1038/s41419-020-02985-x
4. Battson ML, Lee DM, Gentile CL (2016) Endoplasmic reticulum stress and the development of endothelial dysfunction. Am J Physiol Heart Circ Physiol 312:H355–H367. https://doi.org/10.1152/ajpheart.00437.2016
5. Behnammanesh G, Durante ZE, Peyton KJ, Martinez-Lemus LA, Brown SM, Bender SB and Durante W (2019) Canagliflozin inhibits human endothelial cell proliferation and tube formation. Front Pharmacol 10
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