Cytochrome P-450 metabolic-intermediate complex formation with a series of diphenhydramine analogues-Reference-Cited by-同舟云学术

Cytochrome P-450 metabolic-intermediate complex formation with a series of diphenhydramine analogues

Published:1990-04 Issue:1-2 Volume:30 Page:161-165
ISSN:0065-4299
Container-title:Agents and Actions
language:en
Short-container-title:Agents and Actions

Author:

Bast A.,Valk A. J.,Timmerman H.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Toxicology,Pharmacology,Immunology

Link

http://link.springer.com/content/pdf/10.1007/BF01969027.pdf

Reference13 articles.

1. M. R. Franklin,Inhibition of mixed-function oxidations by substrates forming reduced cytochrome P-450 metabolic-intermediate complexes. Pharmacol. Ther. Part A3, 227–245 (1977).

2. A. Bast, E. M. Savenije-Chapel and J. Noordhoek,Relationship between molecular structure and cytochrome P-450-metabolic intermediate complex formation. J. Pharm. Sci.73, 953–956 (1984).

3. U. B. Paulsen-Sörman, K.-H. Jönssen and B. G. A. Lindeke,Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines 8. Stereoselectivity in metabolic intermediary complex formation with a series of chiral 2-substituted 1-phenyl-2-aminoethanes. J. Med. Chem.27, 342–346 (1984).

4. A. Bast and J. Noordhoek,Spectral interactions of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat. Biochem. Pharmacol.31, 2745–2753 (1982).

5. A. Bast, E. M. Savenije-Chapel, F. A. A. van Kemenade, L. W. C. Scheefhals and J. Noordhoek,Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat. Arch. Toxicol.54, 131–137 (1983).

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