A scoping review of studies on the health impact of electronic nicotine delivery systems

Author:

Hajat Cother,Stein Emma,Shantikumar Saran,Niaura Raymond,Ferrara Pietro,Polosa RiccardoORCID

Abstract

AbstractWe conducted a scoping review of studies on health outcomes from electronic nicotine delivery systems (ENDS). The objective was to identify, narratively synthesize, assess the strength and quality of evidence and critically appraise studies that have reported disease end points associated with the use of ENDS. We included published literature on the health impact of ENDS from 01/01/2015 until 01/02/2020 following the PRISMA guidelines using PubMed, Embase, Scopus and Google Scholar. The database search identified 755 studies, and other sources 265; 37 studies met final eligibility criteria. Levels of evidence included 24(65%) cross-sectional, one (2.7%) case–control and six (16%) case studies, four (11%) cohort studies, one (2.7%) randomized controlled trial (RCT) and one (2.7%) meta-analysis; 27(73%) studies reported only on harms, eight (22%) reported on benefits, two (2%) on benefits and harms. Quality ratings were poor in 20 (54%), fair in 9(24%) and good in 8(22%) of studies. In our review, ENDS was not shown to be causative for harmful cardiovascular disease (CVD) outcomes and shown to be beneficial for hypertensive patients. Switching from cigarettes to e-cigarettes resulted in reduced exacerbations of chronic obstructive pulmonary disease (COPD), with no evidence of long-term deterioration in lung function. Mental Health, cancer and mortality were not adequately studied to form any consensus. Our review has not demonstrated ENDS to be causative of harmful CVD outcomes; furthermore switching from cigarettes to e-cigarettes was associated with improved hypertensive control and reduced exacerbations of COPD, with no evidence of increased asthma risk or long-term respiratory harm. Mental health, cancer and mortality outcomes have not been adequately studied to form a conclusion. Overall, the findings of our review did not provide evidence to counter the consensus held by many that ENDS use is safer than the risks posed from smoking cigarettes.

Funder

foundation for a smoke-free world

Università degli Studi di Catania

Publisher

Springer Science and Business Media LLC

Subject

Emergency Medicine,Internal Medicine

Reference95 articles.

1. World Health Organization (2020) Tobacco: Key facts. https://www.who.int/news-room/fact-sheets/detail/tobacco Accessed 5 August 2020

2. McNeill A et al (2018) Evidence review of e-cigarettes and heated tobacco products 2018. A report commissioned by Public Health England. Public Health England, London

3. Public Health England (2015) E-cigarettes: an evidence update. https://www.gov.uk/government/publications/e-cigarettes-an-evidence-update Accessed 6 August 2020

4. Hajek P et al (2019) A randomized trial of E-Cigarettes versus nicotine-replacement therapy. N Engl J Med 380:629–637. https://doi.org/10.1056/nejmoa1808779

5. Mcrobbie H, Bullen C, Hartmann-Boyce J, Hajek P (2014) Electronic cigarettes for smoking cessation and reduction. Cochrane Database of Syst Rev 12:CD010216. https://doi.org/10.1002/14651858.cd010216.pub2

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