Remdesivir-induced bradycardia in patients hospitalized with SARS-CoV2 infection: a possible vagally-mediated mechanism
Author:
Funder
Ministero della Salute
Publisher
Springer Science and Business Media LLC
Subject
Emergency Medicine,Internal Medicine
Link
https://link.springer.com/content/pdf/10.1007/s11739-022-03168-6.pdf
Reference18 articles.
1. Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S et al (2020) Remdesivir for the treatment of covid-19—final report. N Engl J Med 383:1813–1826. https://doi.org/10.1056/NEJMoa2007764
2. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M et al (2020) A trial of Lopinavir-Ritonavir in adults hospitalized with severe covid-19. N Engl J Med 382:1787–1799. https://doi.org/10.1056/NEJMoa2001282
3. Borba MGS, Val FFA, Sampaio VS, Alexandre MAA, Melo GC, Brito M, Mourão MPG, Brito-Sousa JD, Baía-da-Silva D, Guerra MVF et al (2020) Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial. JAMA Netw Open 3:e208857. https://doi.org/10.1001/jamanetworkopen.2020.8857
4. EMA (2020) Veklury. European Medicines Agency. https://www.ema.europa.eu/en/medicines/human/EPAR/veklury. Accessed 10 June, 2022
5. Jorgensen SCJ, Kebriaei R, Dresser LD (2020) Remdesivir: review of pharmacology, pre-clinical data, and emerging clinical experience for COVID-19. Pharmacotherapy 40:659–671. https://doi.org/10.1002/phar.2429
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1. Remdesivir-Induced Bradycardia and Mortality in SARS-CoV-2 Infection, Potential Risk Factors Assessment: A Systematic Review and Meta-Analysis;Journal of Clinical Medicine;2023-12-05
2. Precipitating factors of bradycardia after remdesivir administration: ICU admission and cutoff value for declining heart rate;Journal of Microbiology, Immunology and Infection;2023-10
3. Association of Remdesivir use with bradycardia: A systematic review and meta‐analysis;Journal of Medical Virology;2023-08
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