Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register
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Published:2023-03-25
Issue:4
Volume:18
Page:1049-1063
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ISSN:1828-0447
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Container-title:Internal and Emergency Medicine
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language:en
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Short-container-title:Intern Emerg Med
Author:
Succurro ElenaORCID, Novella Alessio, Nobili Alessandro, Giofrè Federica, Arturi Franco, Sciacqua Angela, Andreozzi Francesco, Pietrangelo Antonello, Sesti Giorgio, Perticone Francesco, Violi Francesco, Corrao Salvatore, Marengoni Alessandra, Tettamanti Mauro, Pasina Luca, Franchi Carlotta, Franchi Carlotta, Tettamanti Mauro, Miglio Gabriella, Tettamanti Mauro, Ardoino Ilaria, Cantiero Silvia, Prisco Domenico, Silvestri Elena, Emmi Giacomo, Bettiol Alessandra, Mattioli Irene, Mazzetti Matteo, Biolo Gianni, Zanetti Michela, Bartelloni Giacomo, Zaccari Michele, Chiuch Massimiliano, Martini Ilaria, Pirro Matteo, Lupattelli Graziana, Bianconi Vanessa, Alcidi Riccardo, Giotta Alessia, Mannarino Massimo R, Girelli Domenico, Busti Fabiana, Marchi Giacomo, Barbagallo Mario, Dominguez Ligia, Beneduce Vincenza, Cacioppo Federica, Corrao Salvatore, Natoli Giuseppe, Mularo Salvatore, Raspanti Massimo, Argano Christiano, Cavallaro Federica, Zoli Marco, Orio Giuseppe, Magnolfi Eleonora, Serafini Giovanni, Brunori Mattia, Lazzari Ilaria, Simili Angelo, Fabio Giovanna, De Amicis Margherita Migone, Luca Giacomo, Scaramellini Natalia, Stefano Valeria, Leoni Simona, Seghezzi Sonia, Di Mauro Alessandra Danuto, Maira Diletta, Mancarella Marta, Lucchi Tiziano, Clerici Marta, Leoni Simona, Bonini Giulia, Conti Federica, Prolo Silvia, Fabrizi Maddalena, Martelengo Miriana, Vigani Giulia, Nicolini Paola, Sabatino Antonio, Miceli Emanuela, Pisati Martina, Pitotti Lavinia, Antoci Valentina, Cambiè Ginevra, Pitotti Lavinia, Antoci Valentina, Pontremoli Roberto, Beccati Valentina, Nobili Giulia, Leoncini Giovanna, Alberto Jacopo, Cattaneo Federico, Anastasio Luigi, Sofia Lucia, Carbone Maria, Cipollone Francesco, Rossi Ilaria, Valeriani Emanuele, D’Ardes Damiano, Cipollone Alessia, Esposito Lucia, Sestili Simona, Angelucci Ermanno, Mancuso Gerardo, Calipari Daniela, Bartone Mosè, Manetti Roberto, Sircana Marta, Berria Maria, Delitala Alessandro, Muscaritoli Maurizio, Molfino Alessio, Petrillo Enrico, Giorgi Antonella, Gracin Christian, Imbimbo Giovanni, Romanelli Giuseppe, Marengoni Alessandra, Volpini Andrea, Lucente Daniela, Manzoni Francesca, Pirozzi Annalisa, Zucchelli Alberto, Geneletti Thelma, Picardi Antonio, Bellelli Giuseppe, Corsi Maurizio, Antonucci Cesare, Sidoli Chiara, Principato Giulia, Bonfanti Alessandra, Szabo Hajnalka, Mazzola Paolo, Piazzoli Andrea, Corsi Maurizio, Tassone Bruno, De Falco Antonio Brucato Teresa, Negro Enrica, Brenna Martino, Trotta Lucia, Fabris Fabrizio, Bertozzi Irene, Bogoni Giulia, Prandini Tancredi, Ratti Francesco, Zurlo Chiara, Cerruti Lorenzo, Cosi Elisabetta, Reni Elisa, Manfredini Roberto, Boari Benedetta, Giorgi Alfredo, Tiseo Ruana, Savriè Caterina, Fabbian Fabio, Paolisso Giuseppe, Catalano Claudia, Meo Irene, Sabbà Carlo, Suppressa Patrizia, De Vincenzo Giovanni Michele, Comitangelo Alessio, Amoruso Emanuele, Custodero Carlo, Re Giuseppe, Barnaba Ivano, Schilardi Andrea, Fenoglio Luigi, Falcetta Andrea, D’Aniano Salvatore, Tiraboschi Silvia, Cespiati Annalisa, Oberti Giovanna, Sigon Giordano, Cinque Felice, Colavolpe Lucia, Currà Jaqueline, Alletto Francesca, Scaramellini Natalia, Leoni Simona, Di Mauro Alessandra Danuta, Benzoni Gianpaolo, Peyvandi Flora, Rossio Raffaella, Colombo Giulia, Agosti Pasquale, Pagliaro Erica, Semproni Eleonora, Canetta Ciro, Monzani Valter, Savojardo Valeria, Ceriani Giuliana, Folli Christian, Tognin Tiziana, Purrello Francesco, Pino Antonino, Piro Salvatore, Rozzini Renzo, Falanga Lina, Boffelli Stefano, Ferrandina Camillo, Mazzeo Francesca, Spazzini Elena, Cono Giulia, Cesaroni Giulia, Violi Francesco, Perri Ludovica, Guasti Luigina, Rotunno Francesca, Castiglioni Luana, Maresca Andrea, Squizzato Alessandro, Campiotti Leonardo, Grossi Alessandra, Dentali Francesco, Behnke Veronica, Perticone Maria, Maio Raffaele, Scozzafava Aleandra, Condoleo Valentino, Clausi Elvira, Armentaro Giuseppe, Panza Alberto, Condoleo Valentino, Stanghellini Vincenzo, Ruggeri Eugenio, Vecchio Sara, Benzoni Ilaria, Minisola Salvatore, Colangelo Luciano, Cilli Mirella, Labbadia Giancarlo, Pepe Jessica, Castellino Pietro, Zanoli Luca, Gaudio Agostino, Xourafa Anastasia, Spichetti Concetta, Torre Serena, Gennaro Alfio, Ballestrero Alberto, Ferrando Fabio, Gonella Roberta, Cerminara Domenico, Setti Paolo, Traversa Chiara, Scarsi Camilla, Famularo Giuseppe, Tarsitani Patrizia, Morretti Tiziana, Aglitti Andrea, Giacco Stefano, Firinu Davide, Costanzo Giulia, Chessa Salvatore, Montalto Giuseppe, Licata Anna, Rizzo Angelo, Corica Francesco, Basile Giorgio, Catalano Antonino, Bellone Federica, Principato Concetto, Cocuzza Angelo, Mecocci Patrizia, Ruggiero Carmelinda, Boccardi Virginia, Meschi Tiziana, Ticinesi Andrea, Nouvenne Antonio, Pirisi Mario, Sola Daniele, Bellan Mattia, Quadri Roberto, Larovere Erica, Novelli Marco, Simeone Emilio, Scurti Rosa, Tolloso Fabio, Tarquini Roberto, Valoriani Alice, Dolenti Silvia, Vannini Giulia, Volpi Riccardo, Bocchi Pietro, Vignali Alessandro, Harari Sergio, Lonati Chiara, Napoli Federico, Aiello Italia, Salvatore Teresa, Monaco Lucio, Ricozzi Carmen, Coviello Francesca, Catalini Christian, Pilotto Alberto, Indiano Ilaria, Gandolfo Federica, Gonella Davide, Nuti Ranuccio, Valenti Roberto, Ruvio Martina, Cappelli Silvia, Palazzuoli Alberto, Durante Vittorio, Tirotta Daniela, Eusebi Giovanna, Tresoldi Moreno, Bozzolo Enrica, Damanti Sarah, Porta Massimo, Gino Miriam, Pari Bianca, Pace Edoardo,
Abstract
AbstractDiabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie–Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria.
Funder
Università degli studi "Magna Graecia" di Catanzaro
Publisher
Springer Science and Business Media LLC
Subject
Emergency Medicine,Internal Medicine
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