Investigation of intrathecal transport of NPT002, a prospective therapeutic based on phage M13, in nonhuman primates

Author:

Papisov Mikhail I.,Belov V.,Belova E.,Fischman A. J.,Fisher R.,Wright J. L.,Gannon K. S.,Titus J.,Gagne M.,Gillooly C. A.

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference22 articles.

1. Karlsson F, Borrebaeck CA, et al. The mechanism of bacterial infection by filamentous phages involves molecular interactions between TolA and phage protein 3 domains. J Bacteriol. 2003;185(8):2628–34.

2. Solomon B. In vivo targeting of amyloid plaques via intranasal administration of phage anti-beta-amyloid antibodies. In: Advances in Alzheimer’s and Parkinson’s Disease. Advances in behavioral biology, vol. 57. New York: Springer; 2008. p. 273–8.

3. Gannon K, et al. NeuroPhage Pharmaceuticals, unpublished data on file. 2011–2012.

4. Gannon KS, Becker M, Lavie V, Tsubery H, Rockenstein E, Masliah E, et al. NPT001 targets Abeta, tau and alpha-synuclein aggregates in biochemical assays and in transgenic mouse models. Annual Meeting of Society for Neuroscience. Washington, DC; 2011.

5. Ksendzovsky A, Walbridge S, Saunders RC, Asthagiri AR, Heiss JD, Lonser RR. Convection-enhanced delivery of bacteriophage to the brain. J Neurosurg. 2012. doi: 10.3171/.2012.4.jns111528 .

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