A proof of concept to define the parameters affecting poly-l-lactide-co-poly-ε-caprolactone shape memory electrospun nanofibers for biomedical applications

Author:

Pisani Silvia,Genta Ida,Modena Tiziana,Dorati Rossella,Bruni Giovanna,Benazzo Marco,Conti BiceORCID

Abstract

Abstract This study is a proof of concept performed to evaluate process parameters affecting shape memory effect of copolymer poly-l-lactide-co-poly-ε-caprolactone (PLA:PCL) 70:30 ratio based nanofibrous scaffolds. A design of experiment (DOE) statistical approach was used to define the interaction between independent material and process variables related to electrospun scaffold manufacturing, such as polymer solution concentration (w/v%), spinning time (min), and needle size (Gauge), and their influence on Rf% (ability of the scaffold to maintain the induced temporary shape) and Rr% (ability of the scaffold to recover its original shape) outputs. A mathematical model was obtained from DOE useful to predict scaffold Rf% and Rr% values. PLA-PCL 15% w/v, 22G needle, and 20-min spinning time were selected to confirm the data obtained from theoretical model. Subsequent morphological (SEM), chemical-physical (GPC and DSC), mechanical (uniaxial tensile tests), and biological (cell viability and adhesion) characterizations were performed. Graphical abstract

Funder

Università degli Studi di Pavia

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

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