Abstract
AbstractThe sesquiterpene abscisic acid (ABA) is an ancient stress response molecule. In plants, many ABA-dependent processes operate via PYR/PYL/RCAR receptor complexes, but results from several studies have suggested that not all plant responses function through this mechanism. Since the ABA-dependent processes of animals and humans also operate in the absence of such receptors, we hypothesize that plant and animal proteomes harbour proteins with undiscovered ABA-binding sites. We propose that carefully curated amino acid search motifs deduced from the binding sites of experimentally confirmed ABA-binding proteins can identify many more candidates in plant and animal proteomes. Some of these candidates show structural folds that are compatible with ABA-binding. This approach identifies plant candidates including annotated ABA downstream signaling components SnRK2.2 and SnRK2.6, and proteins involved in protein folding and RNA polyadenylation. The identified ABA-binding candidates in the human proteome affect among other processes, immune responses and tumor progression. If these candidates are eventually validated experimentally, it will imply that the regulation and tuning of ABA-dependent processes is considerably more complex than hitherto suspected. It will also help to clarify the role of this conserved signaling molecule in mammals.
Funder
National Natural Science Foundation of China
International Collaborative Research Program of Wenzhou-Kean University
MUR–PRIN 2017
Publisher
Springer Science and Business Media LLC
Subject
Plant Science,Agronomy and Crop Science,Physiology
Cited by
2 articles.
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1. Amino acid motifs for the identification of novel protein interactants;Computational and Structural Biotechnology Journal;2023
2. New Horizons in Plant Cell Signaling;International Journal of Molecular Sciences;2022-05-23