Fast liquid chromatographic determination of radiochemical and chemical purity of [11C]methionine by UPLC technique-Reference-Cited by-同舟云学术

Fast liquid chromatographic determination of radiochemical and chemical purity of [11C]methionine by UPLC technique

Published:2020-05-06 Issue:3 Volume:324 Page:1237-1244
ISSN:0236-5731
Container-title:Journal of Radioanalytical and Nuclear Chemistry
language:en
Short-container-title:J Radioanal Nucl Chem

Author:

Rezes Renáta,Csoma Szilvia L.,Németh Enikő,Jószai István^ORCID

Abstract

AbstractUltra-performance liquid chromatographic technique was applied for the first time for determination of radiochemical and chemical purity of [11C]methionine with measurement time less than 2 min. The pH and eluent strength of mobile phase were optimized to achieve a gradient elution for separation of non-radioactive impurities as well as radioactive ingredients. The developed method was validated according to the following parameters: linearity, repeatability, recovery, limit of quantitation. The novel chromatographic procedure with reduced measurement time could be uniquely applied for the quality control of [11C]methionine to considerably shorten the release time and avoid radioactivity loss of radiopharmaceutical.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Spectroscopy,Pollution,Radiology Nuclear Medicine and imaging,Nuclear Energy and Engineering,Analytical Chemistry

Link

https://link.springer.com/content/pdf/10.1007/s10967-020-07179-5.pdf

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