Preliminary evaluation of a 64Cu-labeled DNA aptamer for PET imaging of glioblastoma-Reference-Cited by-同舟云学术

Preliminary evaluation of a 64Cu-labeled DNA aptamer for PET imaging of glioblastoma

Published:2023-02-22 Issue:6 Volume:332 Page:2279-2284
ISSN:0236-5731
Container-title:Journal of Radioanalytical and Nuclear Chemistry
language:en
Short-container-title:J Radioanal Nucl Chem

Author:

Li Pinghui,Wang Chunmei,Wang Wenrui,Duan Xiaoyan,Li Jianbo^ORCID

Abstract

AbstractTo develop a DNA aptamer-based PET tracer for imaging of glioblastoma. 5 mM of NOTA-AS1411, 60-min, and 37 °C were selected as the optimal condition for 64Cu radiolabeling of AS1411. 64Cu-NOTA-AS1411 remained stable in PBS and 100% mouse serum for at least six hours. From the PET images, 64Cu-NOTA-AS1411 tended to be excreted out through the kidneys and there was high tracer accumulation in the bladder. There was a higher tumor uptake in the AS1411 group than that in the control group. 64Cu-NOTA-AS1411 is a suitable potential PET tracer for imaging murine glioblastoma.

Funder

National Natural Science Foundation of China

Education Department of Inner Mongolia Autonomous Region

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Spectroscopy,Pollution,Radiology, Nuclear Medicine and imaging,Nuclear Energy and Engineering,Analytical Chemistry

Link

https://link.springer.com/content/pdf/10.1007/s10967-023-08835-2.pdf

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