Prophylactic Administration with Methylene Blue Improves Hemodynamic Stabilization During Obstructive Jaundice–Related Diseases’ Operation: a Blinded Randomized Controlled Trial
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Published:2023-04-26
Issue:9
Volume:27
Page:1837-1845
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ISSN:1091-255X
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Container-title:Journal of Gastrointestinal Surgery
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language:en
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Short-container-title:J Gastrointest Surg
Author:
Huang Jian,Gao Xian,Wang Moran,Yang Zhen,Xiang Lunli,Li Yongshuai,Yi Bin,Gu Jianteng,Wen Jing,Lu Kaizhi,Zhao Hongwen,Ma Daqing,Chen Li,Ning Jiaolin
Abstract
Abstract
Objectives
Patients with obstruction jaundice are at a high risk of hypotension and need high volume of fluids and a high dose of catecholamine to maintain organ perfusion during operation procedure. All these likely contribute to high perioperative morbidity and mortality. The aim of the study is to evaluate the effects of methylene blue on the hemodynamics in patients undergoing surgeries associated with obstructive jaundice.
Design
A prospective, randomized, and controlled clinical study.
Setting
The enrolled patients randomly received 2 mg/kg of methylene blue in saline or saline (50 ml) before anesthesia induction. The primary outcome was the frequency and dose of noradrenaline administration to maintain mean arterial blood pressure over 65 mmHg or > 80% of baseline, and systemic vascular resistance (SVR) over 800 dyne/s/cm5 during operation. The secondary outcomes were liver and kidney functions, and ICU stay.
Patients
Seventy patients were enrolled in the study and randomly assigned to receive either methylene blue or control (n = 35/group).
Results
Fewer patients received noradrenaline in the methylene blue group when compared with the control group (13/35 vs 23/35, P = 0.017), and the noradrenaline dose administrated during operation was reduced in the methylene blue group when compared with the control group (0.32 ± 0.57 mg vs 1.787 ± 3.51 mg, P = 0.018). The blood level of creatinine, glutamic oxalacetic transaminase, and glutamic–pyruvic transaminase after the operation was reduced in the methylene blue group when compared with the control group.
Conclusions
Prophylactic administration of methylene blue before operation associated with obstructive jaundice improves hemodynamic stability and short-term prognosis.
Question
Methylene blue use prevented refractory hypotension during cardiac surgery, sepsis, or anaphylactic shock. It is still unknown that methylene blue on the vascular hypo-tone associated with obstructive jaundice.
Findings
Prophylactic administration with methylene blue improved peri-operative hemodynamic stability, and hepatic and kidney function on the patients with obstructive jaundice.
Meanings
Methylene blue is a promising and recommended drug for the patients undergoing the surgeries of relief obstructive jaundice during peri-operation management.
Funder
the innovation grant from Southwest hospital, Third Military Medical University
Subject
Gastroenterology,Surgery
Reference27 articles.
1. van der Gaag NA, de Castro SM, Rauws EA, et al. Preoperative biliary drainage for periampullary tumors causing obstructive jaundice; DRainage vs. (direct) OPeration (DROP-trial). BMC SURG. 2007; 7: 3.
2. Cashore W. A brief history of neonatal jaundice. Med Health R I. 2010; 93: 154-155.
3. Koyama K. [Pathophysiology of obstructive jaundice and its surgical problems]. Nihon Geka Gakkai Zasshi. 1985; 86: 1004-1007.
4. Lucas WB, Chuttani R. Pathophysiology and current concepts in the diagnosis of obstructive jaundice. Gastroenterologist. 1995; 3: 105-118.
5. NIELUBOWICZ J. [PATHOPHYSIOLOGY OF JAUNDICE]. Pol PrzeglChir. 1963; 35: 695-701.
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