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An Explainable Machine-Learning Model to Analyze the Effects of a PCSK9 Inhibitor on Thrombolysis in STEMI Patients

  • Published:2023-05-31 Issue:3 Volume:43 Page:339-349
  • ISSN:1609-0985
  • Container-title:Journal of Medical and Biological Engineering
  • language:en
  • Short-container-title:J. Med. Biol. Eng.

Author:

Zhao PengyuORCID,Zhou Jia,Liu Chang,Li Zhaoying,He Ping,Li Chunjie,Zhao Jia,Hou Yonghong

Funder

Tianjin Key Research Program of Traditional Chinese Medicine

Tianjin Research Innovation Project for Postgraduate Students

National Natural Science Foundation of China

Applied and Basic Research by Multi-input Foundation of Tianjin

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,General Medicine

Reference47 articles.

1. Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Stroke Statistics, S. (2021). Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. Circulation, 143(8), 254-e743. https://doi.org/10.1161/CIR.0000000000000950

2. O’Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Jr., Chung, M. K., de Lemos, J. A., American College of Cardiology Foundation, American Heart Association Task Force on Practice, G. (2013). 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 127(4), e362-425. https://doi.org/10.1161/CIR.0b013e3182742cf6

3. Ibanez, B., James, S., Agewall, S., Antunes, M. J., Bucciarelli-Ducci, C., Bueno, H., Group, E. S. C. S. D. (2018). ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal, 39(2), 119–177. https://doi.org/10.1093/eurheartj/ehx393

4. Fazel, R., Joseph, T. I., Sankardas, M. A., Pinto, D. S., Yeh, R. W., Kumbhani, D. J., & Nallamothu, B. K. (2020). Comparison of reperfusion strategies for ST-segment-elevation myocardial infarction: A multivariate network meta-analysis. Journal of American Heart Association, 9(12), e015186. https://doi.org/10.1161/JAHA.119.015186

5. Gurewich, V. (2016). Thrombolysis: A critical first-line therapy with an unfulfilled potential. American Journal of Medicine, 129(6), 573–575. https://doi.org/10.1016/j.amjmed.2015.11.033
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