Author:
Yang Nan,Xiao Wanyue,Song Xuejiao,Wang Wenjun,Dong Xiaochen
Abstract
AbstractPhotodynamic therapy (PDT), as one of the noninvasive clinical cancer phototherapies, suffers from the key drawback associated with hypoxia at the tumor microenvironment (TME), which plays an important role in protecting tumor cells from damage caused by common treatments. High concentration of hydrogen peroxide (H2O2), one of the hallmarks of TME, has been recognized as a double-edged sword, posing both challenges, and opportunities for cancer therapy. The promising perspectives, strategies, and approaches for enhanced tumor therapies, including PDT, have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine. In this review, we outline the latest advances in H2O2-responsive materials, including organic and inorganic materials for enhanced PDT. Finally, the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned.
Publisher
Springer Science and Business Media LLC
Subject
Electrical and Electronic Engineering,Surfaces, Coatings and Films,Electronic, Optical and Magnetic Materials
Reference73 articles.
1. K.D. Miller, R.L. Siegel, C.C. Lin, A.B. Mariotto, J.L. Kramer et al., Cancer treatment and survivorship statistics. CA Cancer J. Clin. 66(4), 271–289 (2016). https://doi.org/10.3322/caac.21349
2. D. Luo, K.A. Carter, D. Miranda, J.F. Lovell, Chemophototherapy: an emerging treatment option for solid tumors. Adv. Sci. 4(1), 1600106 (2017). https://doi.org/10.1002/advs.201600106
3. I.F. Tannock, C.M. Lee, J.K. Tunggal, D.S.M. Cowan, M.J. Egorin, Limited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapy. Clin. Cancer Res. 8(3), 878–884 (2002)
4. A.P. Castano, P. Mroz, M.R. Hamblin, Photodynamic therapy and anti-tumour immunity. Nat. Rev. Cancer 6(7), 535–545 (2006). https://doi.org/10.1038/nrc1894
5. P.N. Manghnani, W. Wu, S. Xu, F. Hu, C. The, B. Liu, Visualizing photodynamic therapy in transgenic zebrafish using organic nanoparticles with aggregation-induced emission. Nano-Micro Lett. 10, 61 (2018). https://doi.org/10.1007/s40820-018-0214-4
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