High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography
-
Published:2022-06-14
Issue:1
Volume:14
Page:
-
ISSN:2311-6706
-
Container-title:Nano-Micro Letters
-
language:en
-
Short-container-title:Nano-Micro Lett.
Author:
Li Junshi,Ma Yundong,Huang Dong,Wang Zhongyan,Zhang Zhitong,Ren Yingjie,Hong Mengyue,Chen Yufeng,Li Tingyu,Shi Xiaoyi,Cao Lu,Zhang Jiayan,Jiao Bingli,Liu Junhua,Sun Hongqiang,Li Zhihong
Abstract
Highlights
Polyimide-based flexible microneedle array (PI-MNA) electrodes realize high electrical/mechanical performance and are compatible with wearable wireless recording systems.
The normalized electrode–skin interface impedance (EII) of the PI-MNA electrodes reaches 0.98 kΩ cm2 at 1 kHz and 1.50 kΩ cm2 at 10 Hz, approximately 1/250 of clinical standard electrodes.
This is the first report on the clinical study of microneedle electrodes. The PI-MNA electrodes are applied to clinical long-term continuous monitoring for polysomnography.
Abstract
Microneedle array (MNA) electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications. Existing schemes are limited by flexibility, biosafety, and manufacturing costs, which create large barriers for wider applications. Here, we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface, robustness of microneedles to penetrate the skin without fracture, and a simplified process to allow mass production. The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording. The normalized electrode–skin contact impedance reaches 0.98 kΩ cm2 at 1 kHz and 1.50 kΩ cm2 at 10 Hz, a record low value compared to previous reports and approximately 1/250 of the standard electrodes. The morphology, biosafety, and electrical/mechanical properties are fully characterized, and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized. The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording (over 8 h per night), providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes.
Funder
Shanghai Jiao Tong University
Publisher
Springer Science and Business Media LLC
Subject
Electrical and Electronic Engineering,Surfaces, Coatings and Films,Electronic, Optical and Magnetic Materials
Reference54 articles.
1. Y. Ling, T. An, L.W. Yap, B. Zhu, S. Gong et al., Disruptive, soft, wearable sensors. Adv. Mater. 32(18), 1904664 (2020). https://doi.org/10.1002/adma.201904664 2. T.R. Ray, J. Choi, A.J. Bandodkar, S. Krishnan, P. Gutruf et al., Bio-integrated wearable systems: a comprehensive review. Chem. Rev. 119(8), 5461–5533 (2019). https://doi.org/10.1021/acs.chemrev.8b00573 3. Y.H. Wang, L. Yin, Y.Z. Bai, S.Y. Liu, L. Wang et al., Electrically compensated, tattoo-like electrodes for epidermal electrophysiology at scale. Sci. Adv. 6(43), abd0996 (2020). https://doi.org/10.1126/sciadv.abd0996 4. L. Tian, B. Zimmerman, A. Akhtar, K.J. Yu, M. Moore et al., Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring. Nat. Biomed. Eng. 3(3), 194–205 (2019). https://doi.org/10.1038/s41551-019-0347-x 5. L.F. Wang, J.Q. Liu, B. Yang, C.S. Yang, PDMS-based low cost flexible dry electrode for long-term EEG measurement. IEEE Sens. J. 12(9), 2898–2904 (2012). https://doi.org/10.1109/jsen.2012.2204339
Cited by
25 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|