Effect of phenobarbital andp-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: Use of a kinetic model to examine the rates of formation and egress

Author:

Studenberg Scott D.,Brouwer Kim L. R.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Reference30 articles.

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3. G. M. M. Groothuis, C. E. Hulstaert, D. Kalicharan, and M. Hardonk. Plasma membrane specialization and intracellular polarity of freshly isolated rat hepatocytes.Eur. J. Cell. Biol. 26:43–51 (1981).

4. S. Kato, K. Aoyama, T. Nakamura, and A. Ichihara. Biochemical studies on liver func-tions in primary cultured hepatocytes of adult rats. III. Changes of enzyme activities on cell membranes during culture.J. Biochem. 86:1419–1425 (1979).

5. A. Blom, A. H. Scaf, and D. K. F. Meijer. Hepatic drug transport in the rat. A comparison between isolated hepatocytes, the isolated perfused liver and the liverin vivo.Biochem. Pharmacol. 31:1553–1565 (1982).

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