Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users-Reference-Cited by-同舟云学术

Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

Published:2018-04-05 Issue:2 Volume:36 Page:359-374
ISSN:1860-8965
Container-title:Forensic Toxicology
language:en
Short-container-title:Forensic Toxicol

Author:

McKenzie Craig^ORCID,Sutcliffe Oliver B.^ORCID,Read Kevin D.,Scullion Paul,Epemolu Ola,Fletcher Daniel,Helander Anders^ORCID,Beck Olof^ORCID,Rylski Alexia,Antonides Lysbeth H.,Riley Jennifer,Smith Shannah A.^ORCID,Nic Daeid Niamh^ORCID

Funder

Engineering and Physical Sciences Research Council

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry, medical,Toxicology,Pathology and Forensic Medicine

Link

http://link.springer.com/article/10.1007/s11419-018-0413-1/fulltext.html

Reference37 articles.

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2. EMCDDA (2014) EMCDDA–Europol Joint Report on a new psychoactive substance: 1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (‘MT-45’). http://www.emcdda.europa.eu/system/files/publications/810/TDAS14007ENN_477731.pdf_en . Accessed 25 Aug 2017

3. European Patent Office (1976) 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof. US Patent 3,957,788. Issued 18th May 1976. https://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=3957788&KC=&FT=E&locale=en_EP . Accessed 21 Aug 2017

4. Nakamura H, Shimizu M (1976) Comparative study of 1-(cyclohexyl-4-(1,2-diphenylethyl)- piperazine (MT-45) and its enantiomorphs on analgesic and other pharmacological activities in experimental animals. Arch Int Pharmacodyn Ther 221:105–121

5. Prekupec M, Mansky P, Baumann M (2017) Misuse of novel synthetic opioids: a deadly new trend. J Addict Med 11:256–265

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