Simultaneous analysis of sildenafil, vardenafil, tadalafil, and their desalkyl metabolites in human whole blood and urine by isotope dilution LC–MS

Simultaneous analysis of sildenafil, vardenafil, tadalafil, and their desalkyl metabolites in human whole blood and urine by isotope dilution LC–MS–MS

Published:2011-11-29 Issue:1 Volume:30 Page:25-32
ISSN:1860-8965
Container-title:Forensic Toxicology
language:en
Short-container-title:Forensic Toxicol

Author:

Hasegawa Koutaro,Suzuki Osamu,Gonmori Kunio,Yamagishi Itaru,Nozawa Hideki,Watanabe Kanako

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry, medical,Toxicology,Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1007/s11419-011-0125-2.pdf

Reference16 articles.

1. Padma-Nathan H (2005) Sildenafil citrate, the classic PDE 5 inhibiter, a five-year review of its efficacy and safety in the arena of erectile dysfunction. In: Gregory AP (ed) Oral pharmacotherapy for male sexual dysfunction. A guide to clinical management. Humana, Totowa, pp 65–83

2. Yang W, Lee S, Choi Y, Chung H (2009) Importance of sildenafil analysis for drug screening of postmortem specimens: demonstration of five autopsy cases involving sildenafil. Forensic Toxicol 27:107–109

3. Kudo K, Ishida T, Hikiji W, Usumoto Y, Umehara T, Nagamatsu K, Tsuji A, Ikeda N (2010) Pattern of poisoning in Japan: selection of drugs and poisons for systematic toxicological analysis. Forensic Toxicol 28:25–32

4. Singh S, Prasad B, Savaliya AA, Shah RP, Gohil VM, Kaur A (2009) Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs. Trends Anal Chem 28:13–28

5. Man CN, Nor NM, Lajis R, Harn GL (2009) Identification of sildenafil, tadalafil and vardenafil by gas chromatography-mass spectrometry on short capillary column. J Chromatogr A 1216:8426–8430

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A green liquid phase microextraction using phthalic acid as switchable hydrophilicity solvent for the HPLC determination of sildenafil (Viagra®) in human urine;Microchemical Journal;2024-09

2. A novel 1T-2H MoS2/NaBi(MoO4)2 alternating-phase piezoelectric composites for high-efficient ultrasound-drived piezoelectric catalytic removal of Sildenafil;Process Safety and Environmental Protection;2023-11

3. Postmortem Toxicology of Tadalafil in a Forensic Case;International Journal of Medical Toxicology and Forensic Medicine;2023-09-24

4. Multi-Interface polarization engineering constructed 1T-2H MoS2 QDs/Y-NaBi(MoO4)2 multiple heterostructure for high-efficient piezoelectric-photoelectrocatalysis PDE-5i degradation;Applied Catalysis B: Environmental;2023-06

5. Contribution of sewage to occurrence of phosphodiesterase-5 inhibitors in natural water;Scientific Reports;2021-05-04