In vitro toxicokinetics and analytical toxicology of three novel NBOMe derivatives: phase I and II metabolism, plasma protein binding, and detectability in standard urine screening approaches studied by means of hyphenated mass spectrometry-Reference-Cited by-同舟云学术

In vitro toxicokinetics and analytical toxicology of three novel NBOMe derivatives: phase I and II metabolism, plasma protein binding, and detectability in standard urine screening approaches studied by means of hyphenated mass spectrometry

Published:2019-08-26 Issue:1 Volume:38 Page:141-159
ISSN:1860-8965
Container-title:Forensic Toxicology
language:en
Short-container-title:Forensic Toxicol

Author:

Richter Lilian H. J.,Menges Julia,Wagmann Lea,Brandt Simon D.,Stratford Alexander,Westphal Folker,Flockerzi Veit,Meyer Markus R.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry (medical),Toxicology,Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1007/s11419-019-00498-7.pdf

Reference38 articles.

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2. Tettey JNA, Crean C, Ifeagwu SC, Raithelhuber M (2018) Emergence, diversity, and control of new psychoactive substances: a global perspective. Handb Exp Pharmacol 252:51–67

3. Halberstadt AL (2017) Pharmacology and toxicology of N-benzylphenethylamine (“NBOMe”) hallucinogens. Curr Topic Behav Neurosci 32:283–311

4. Caspar AT, Brandt SD, Stoever AE, Meyer MR, Maurer HH (2017) Metabolic fate and detectability of the new psychoactive substances 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25B-NBOMe) and 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25C-NBOMe) in human and rat urine by GC-MS, LC-MS(n), and LC-HR-MS/MS approaches. J Pharm Biomed Anal 134:158–169

5. Caspar AT, Helfer AG, Michely JA, Auwarter V, Brandt SD, Meyer MR et al (2015) Studies on the metabolism and toxicological detection of the new psychoactive designer drug 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe) in human and rat urine using GC-MS, LC-MS(n), and LC-HR-MS/MS. Anal Bioanal Chem 407:6697–6719

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