A model system for prediction of the in vivo metabolism of designer drugs using three-dimensional culture of rat and human hepatocytes-Reference-Cited by-同舟云学术

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A model system for prediction of the in vivo metabolism of designer drugs using three-dimensional culture of rat and human hepatocytes

Published:2011-06-04 Issue:2 Volume:29 Page:142-151
ISSN:1860-8965
Container-title:Forensic Toxicology
language:en
Short-container-title:Forensic Toxicol

Author:

Kanamori Tatsuyuki,Kuwayama Kenji,Tsujikawa Kenji,Miyaguchi Hajime,Togawa-Iwata Yuko,Inoue Hiroyuki

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry, medical,Toxicology,Pathology and Forensic Medicine

Link

http://link.springer.com/content/pdf/10.1007/s11419-011-0116-3.pdf

Reference17 articles.

1. Jornil J, Linnet K (2009) Roles of polymorphic enzymes CYP2D6 and CYP2C19 for in vitro metabolism of amitriptyline at therapeutic and toxic levels. Forensic Toxicol 27:12–20

2. Cross DM, Bayliss MK (2000) A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development. Drug Metab Rev 32:219–240

3. Bader A, Zech K, Crome O, Christians U, Ringe B, Pichlmayr R, Sewing KF (1994) Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica 24:623–633

4. Bayliss MK, Bell JA, Jenner WN, Park GR, Wilson K (1999) Utility of hepatocytes to model species differences in the metabolism of loxidine and to predict pharmacokinetic parameters in rat, dog and man. Xenobiotica 29:253–268

5. Gebhardt R, Hengstler JG, Müller D, Glöckner R, Buenning P, Laube B, Schmelzer E, Ullrich M, Utesch D, Hewitt N, Ringel M, Hilz BR, Bader A, Langsch A, Koose T, Burger HJ, Maas J, Oesch F (2003) New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug Metab Rev 35:145–213

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1. Proposal of 5-methoxy- N -methyl- N -isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice;Journal of Chromatography A;2017-07

2. Investigating Drug Metabolism of New Psychoactive Substances Using Human Liver Preparations and Animal Studies;Forensic Toxicology: Drug Use and Misuse;2016-07-14

3. Evaluation ofin vitrometabolic systems for common drugs of abuse. 1. Cocaine;Xenobiotica;2013-05-15

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