Author:
Roussakis Andreas-Antonios,Zeng Zhou,Lao-Kaim Nicholas P.,Martin-Bastida Antonio,Piccini Paola,Barker Roger A.,Farrell Krista,Guzman Natalie Valle,He Xiaoling,Lazic Stanley E.,Moore Sarah,Morris Robert,Tyers Pamela,Wijeyekoon Ruwani,Daft Danielle,Hewitt Sam,Dayal Biswas,Foltynie Thomas,Kefalopoulou Zenobia,Mahlknecht Philipp,Bjartmarz Hjalmar,Björklund Anders,Lindvall Olle,Nelander-Wahlestedt Jenny,Parmar Malin,Paul Gesine,Widner Hakan,Church Alistair,Dunnett Stephen,Peall Kathryn,Rosser Anne,Gurruchaga Jean Marc,Palfi Stéphane,Piroth Tobias,Winkler Christian,
Abstract
AbstractAsymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.
Funder
7th Framework Programme
the Medical Research Council
the NIHR Biomedical Research Centres of Imperial College and University of Cambridge/Addenbrooke's Hospital
the Swedish Parkinson Academy
Swedish Regional Academic Learning Grants
the NIHR Imperial Clinical Research Facility
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),Neurology