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Relationship between ‘on-treatment platelet reactivity’, shear stress, and micro-embolic signals in asymptomatic and symptomatic carotid stenosis

  • Published:2019-10-12 Issue:1 Volume:267 Page:168-184
  • ISSN:0340-5354
  • Container-title:Journal of Neurology
  • language:en
  • Short-container-title:J Neurol

Author:

Murphy S. J. X.ORCID,Lim S. T.,Kinsella J. A.,Tierney S.,Egan B.,Feeley T. M.,Murphy S. M.,Walsh R. A.,Collins D. R.,Coughlan T.,O’Neill D.,Harbison J. A.,Madhavan P.,O’Neill S. M.,Colgan M. P.,Cox D.,Moran N.,Hamilton G.,Meaney J. F.,McCabe D. J. H.ORCID

Funder

Trinity College Dublin Innovation Bursary

Meath Foundation

Joint IICN/Merck Serono Fellowship in Neuroscience

The Vascular Neurology Research Foundation

Bayer HealthCare Ireland

Verum Diagnostica

The Irish Institute of Clinical Neuroscience (IICN)/Novartis Ireland Fellowship Grant

The Irish Heart Foundation Stroke Prevention Bursary

Biogen Idec

Publisher

Springer Science and Business Media LLC

Subject

Neurology (clinical),Neurology

Reference55 articles.

1. McCabe DJ, Harrison P, Mackie IJ, Sidhu PS, Purdy G, Lawrie AS, Watt H, Brown MM, Machin SJ (2004) Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack. Br J Haematol 125(6):777–787. https://doi.org/10.1111/j.1365-2141.2004.04983.x

2. McCabe DJ, Harrison P, Mackie IJ, Sidhu PS, Purdy G, Lawrie AS, Watt H, Machin SJ, Brown MM (2005) Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis. J Neurol Neurosurg Psychiatry 76(9):1249–1254. https://doi.org/10.1136/jnnp.2004.051003

3. McCabe DJ, Harrison P, Mackie IJ, Sidhu PS, Lawrie AS, Purdy G, Machin SJ, Brown MM (2005) Assessment of the antiplatelet effects of low to medium dose aspirin in the early and late phases after ischaemic stroke and TIA. Platelets 16(5):269–280. https://doi.org/10.1080/09537100400020567

4. Jurk K, Ritter MA, Schriek C, Van Aken H, Droste DW, Ringelstein EB, Kehrel BE (2010) Activated monocytes capture platelets for heterotypic association in patients with severe carotid artery stenosis. Thromb Haemost 103(6):1193–1202. https://doi.org/10.1160/TH09-09-0620

5. Tobin WO, Kinsella JA, Coughlan T, Collins DR, O’Neill D, Murphy RP, Egan B, Tierney S, Feeley TM, McCabe DJ (2013) High on-treatment platelet reactivity on commonly prescribed antiplatelet agents following transient ischaemic attack or ischaemic stroke: results from the Trinity Antiplatelet Responsiveness (TRAP) study. Eur J Neurol 20(2):344–352. https://doi.org/10.1111/j.1468-1331.2012.03861.x
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