The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease
-
Published:2020-08-18
Issue:2
Volume:268
Page:448-454
-
ISSN:0340-5354
-
Container-title:Journal of Neurology
-
language:en
-
Short-container-title:J Neurol
Author:
Picillo MarinaORCID, Palladino Raffaele, Erro Roberto, Alfano Rossella, Colosimo Carlo, Marconi Roberto, Antonini Angelo, Barone Paolo, Antonini Angelo, Colosimo Carlo, Marconi Roberto, Morgante Letterio, Benincasa D., Quatrale R., Biguzzi S., Braga M., Ceravolo G., Capecci M., Meco G., Caravona N., Scala R., De Falco F. A., Pezzoli G., De Gaspari D., Bottacchi E., Di Giovanni M., Cannas A., Floris G., Gallerini S., Grasso L., Gaglio R. M., Gurgone G., Volpe G., Zappulla S., Ceravolo R., Kiferle L., Ramat S., Meoni S., Pisani A., Moschella V., Morgante F., Savica R., Pepe F., Ciccarelli G., Petretta V., Giglia R. M., Randisi M. G., Iemolo F., Avarello T. P., Romeno M., Santangelo G., Stocchi F., Sciortino G., Sorbello V., Nicoletti A., Tiple D., Fabbrini G., Bentivoglio A., Pontieri F. E., Guidubaldi A., Muoio R., Toni V., Del Dotto P., Logi C., Ciacci G., Ulivelli M., Perini M., Lanfranchi S., Griffini S., Troianiello B., Baratti M., Amidei S., Consoli D., Iellamo M., Cuomo T., Scaglioni A., Medici D., Manfredi M., Abbruzzese G., Di Brigida G., Cocco G. A., Agnetti V., Cossu G., Deriu M., Abrignani M., Modica C., Albani G., Milan E., Martinelli P., Scaglione C., Mucchiut M., Zanini S., Pennisi F., Soliveri P, Albanese A., Massimo Pederzoli, Bartolomei L., Capus L., Ferigo L., Marano R., Nastasi V., Luciano R., Maiello L., Simone P., Fogli D., Lopiano L., Pesare M., Nordera G., Pilleri E., Scaravilli T., Giaccaglini E., Alesi C., Petrone A., Trianni G.,
Abstract
Abstract
Objectives
To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages.
Methods
A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women).
Results
As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only.
Conclusions
Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.
Funder
Boehringer Ingelheim
Publisher
Springer Science and Business Media LLC
Subject
Clinical Neurology,Neurology
Reference21 articles.
1. Heizel S, Berg D, Gasser T, Chen H, Yao C, Postuma RB, MDS Task Force on the Definition of Parkinson’s Disease (2019) Update of the MDS Research criteria for prodromal Parkinson’s disease. Mov Disord 34:1464–1470 2. Pilotto A, Heinzel S, Suenkel U, Lerche S, Brockmann K, Roeben B, Schaeffer E, Wurster I, Yilmaz R, Liepelt-Scarfone I, von Thaler AK, Metzger FG, Eschweiler GW, Postuma RB, Maetzler W, Berg D (2017) Application of the Movement Disorder Society prodromal Parkinson’s disease research criteria in 2 independent prospective cohorts. Mov Disord 32(7):1025–1034 3. Schrag A, Anastasiou Z, Ambler G, Noyce A, Walters K (2020) Predicting diagnosis of Parkinson’s disease: a risk algorithm based on primary care presentations. Mov Disord 34(2):480–486 4. Heinzel S, Kasten M, Behnke S, Vollstedt EJ, Klein C, Hagenah J, Pausch C, Heilmann R, Brockmann K, Suenkel U, Yilmaz R, Liepelt-Scarfone I, Walter U, Berg D (2018) Age- and sex-related heterogeneity in prodromal Parkinson’s disease. Mov Disord 33(6):1025–1027 5. Cottone C, Tosetti C, Disclafani G, Ubaldi E, Cogliandro R, Stanghellini V (2014) Clinical features of constipation in general practice in Italy. United Eur Gatroenterol J 2(3):232–238
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|