Abstract
Abstract
Introduction
COVID-19 restrictive containment was responsible for major psychological distress and alteration of quality of life (QoL) in the general population. Their impact in a group of patients having cerebral small vessel disease (SVD) and at high risk of stroke and disability was unknown.
Objective
We aimed to determine the potential psychological impact of strict containment during the COVID-19 pandemic in a sample of CADASIL patients, a rare SVD caused by NOTCH3 gene mutations.
Methods
Interviews of 135 CADASIL patients were obtained just after the end of the strict containment in France. Depression, QoL and negative subjective experience of the containment were analysed, as well as predictors of posttraumatic and stressor-related manifestations, defined as an Impact Event Scale-Revised score ≥ 24, using multivariable logistic analysis.
Results
Only 9% of patients showed a depressive episode. A similar proportion had significant posttraumatic and stressor-related disorder manifestations independently associated only with socio-environment factors, rather than clinical ones: living alone outside a couple (OR 7.86 (1.87–38.32), unemployment (OR 4.73 (1.17–18.70)) and the presence of 2 or more children at home (OR 6.34 (1.35–38.34).
Conclusion
Psychological impact of the containment was limited in CADASIL patients and did not appear related to the disease status. About 9% of patients presented with significant posttraumatic and stressor-related disorder manifestations which were predicted by living alone, unemployment, or exhaustion related to parental burden.
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),Neurology
Reference47 articles.
1. DSM-5 - Manuel diagnostique et statistique des troubles mentaux 5 edition. In: Crocq M-A, Guelfi J-D, Boyer P, Pull C-B, Pull M-C (eds) American Psychiatric Association, Masson, France
2. Adamczyk K (2017) Voluntary and involuntary singlehood and young adults’ mental health: an investigation of mediating role of romantic loneliness. Curr Psychol 36:888–904
3. Association AP (2000) Diagnostic and statistical manual of mental disorders, 4th edition, text revision (DSM-IV-TR). American Psychiatric Association
4. Asukai N, Kato H, Kawamura N, Kim Y, Yamamoto K, Kishimoto J, Miyake Y, Nishizono-Maher A (2002) Reliability and validity of the Japanese-language version of the impact of event scale-revised (IES-R-J): four studies of different traumatic events. J Nerv Ment Dis 190:175–182
5. Bendau A, Kunas SL, Wyka S, Petzold MB, Plag J, Asselmann E, Strohle A (2021) Longitudinal changes of anxiety and depressive symptoms during the COVID-19 pandemic in Germany: the role of pre-existing anxiety, depressive, and other mental disorders. J Anxiety Disord 79:102377