Noisy galvanic vestibular stimulation improves vestibular perception in bilateral vestibulopathy

Abstract

Abstract Background Patients with bilateral vestibulopathy (BVP) suffer from impaired vestibular motion perception that is linked to deficits in spatial memory and navigation. Objective To examine the potential therapeutic effect of imperceptible noisy galvanic vestibular stimulation (nGVS) on impaired vestibular perceptual performance in BVP. Methods In 11 patients with BVP (mean age: 54.0 ± 8.3 years, 7 females), we initially determined the nGVS intensity that optimally stabilizes balance during a static posturographic assessment. Subsequently, effects of optimal nGVS vs. sham stimulation on vestibular motion perception were examined in randomized order. Vestibular perceptual performance was determined as direction recognition thresholds for head-centered roll tilt motion on a 6DOF motion platform in the absence of any visual or auditory motion cues. Results For each patient, an nGVS intensity that optimally stabilized static balance compared to sham stimulation could be identified (mean 0.36 ± 0.16 mA). nGVS at optimal intensity resulted in lowered vestibular perceptual thresholds (0.94 ± 0.30 deg/s) compared to sham stimulation (1.67 ± 1.11 deg/s; p = 0.040). nGVS-induced improvements in vestibular perception were observed in 8 of 11 patients (73%) and were greater in patients with poorer perceptual performance during sham stimulation (R = − 0.791; p = 0.007). Conclusions nGVS is effective in improving impaired vestibular motion perception in patients with BVP, in particular in those patients with poor baseline perceptual performance. Imperceptible vestibular noise stimulation might thus offer a non-invasive approach to target BVP-related impairments in spatial memory, orientation, and navigation.