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Combined therapy of intensive statin plus intravenous rt-PA in acute ischemic stroke: the INSPIRE randomized clinical trial

  • Published:2021-02-08 Issue:7 Volume:268 Page:2560-2569
  • ISSN:0340-5354
  • Container-title:Journal of Neurology
  • language:en
  • Short-container-title:J Neurol

Author:

Yang Wan-Yong,Li Yu-Feng,Wang Zi-Ran,Yu Tian-Xia,Xu Dong-Juan,Yang Nan,Niu Xiao-Yuan,Cai Xue-Li,Zhuo Wen-Yan,Wu Xue-Mei,Yan Min,Zhou Jun-Shan,Zhang Hao-Wen,Liang Zhi-Gang,Wu Wen-Jun,Cheng Jian-Hua,Huang Li-An,Zhang Yu-Sheng,Guan Ying,Tan Ze-Feng,Lu Dan,He Niu,Dong Da-Wei,Zhu Hui-Li,Yang Bing,Shen Qing-Yu,Xu An-DingORCID

Funder

National Natural Science Foundation of China

the Guangzhou Science and Technology Program of China

the Science and Technology Program of Guangdong

Guangdong Natural Science Foundation

Publisher

Springer Science and Business Media LLC

Subject

Neurology (clinical),Neurology

Reference31 articles.

1. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, O’Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C (2014) Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet (London, England) 383(9913):245–254. https://doi.org/10.1016/s0140-6736(13)61953-4

2. Furie KL, Jayaraman MV (2018) 2018 Guidelines for the early management of patients with acute ischemic stroke. Stroke 49(3):509–510. https://doi.org/10.1161/strokeaha.118.020176

3. Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW Jr, Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H (2013) Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44(3):870–947. https://doi.org/10.1161/STR.0b013e318284056a

4. Xu AD, Wang YJ, Wang DZ (2013) Consensus statement on the use of intravenous recombinant tissue plasminogen activator to treat acute ischemic stroke by the Chinese Stroke Therapy Expert Panel. CNS Neurosci Ther 19(8):543–548. https://doi.org/10.1111/cns.12126

5. Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis S, Donnan G, Grotta J, Howard G, Kaste M, Koga M, von Kummer R, Lansberg M, Lindley RI, Murray G, Olivot JM, Parsons M, Tilley B, Toni D, Toyoda K, Wahlgren N, Wardlaw J, Whiteley W, del Zoppo GJ, Baigent C, Sandercock P, Hacke W (2014) Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet (London, England) 384(9958):1929–1935. https://doi.org/10.1016/s0140-6736(14)60584-5
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