Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study

Author:

Abtahi ShahabORCID,Pajouheshnia Romin,Durán Carlos E.,Riera-Arnau Judit,Gamba Magdalena,Alsina Ema,Hoxhaj Vjola,Andersen Morten,Bartolini Claudia,Kristiansen Sarah Brøgger,Brown Jeremy,Hallgreen Christine Erikstrup,Garcia-Poza Patricia,Gardarsdottir Helga,Gini Rosa,Girardi Anna,Holthuis Emily,Huerta Consuelo,Ibánez Luisa,Limoncella Giorgio,Martín-Pérez Mar,Paoletti Olga,Roberto Giuseppe,Souverein Patrick,Swart Karin M. A.,Wing Kevin,Sturkenboom Miriam,Klungel Olaf

Funder

European Medicines Agency

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Toxicology

Reference34 articles.

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2. Weston J, Bromley R, Jackson CF, et al. Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child. Cochrane Database Syst Rev. 2016;11(11): CD010224.

3. Wieck A, Jones S. Dangers of valproate in pregnancy. BMJ. 2018;18(361): k1609.

4. Reynolds EH, Green R. Valproate and folate: congenital and developmental risks. Epilepsy Behav. 2020;108: 107068.

5. Tomson T, Battino D, Bonizzoni E, et al. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol. 2018;17(6):530–8.

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