A Comparison of Signals of Designated Medical Events and Non-designated Medical Events: Results from a Scoping Review

Author:

Sartori DanieleORCID,Aronson Jeffrey K.ORCID,Erlanson Nils,Norén G. NiklasORCID,Onakpoya Igho J.ORCID

Funder

Uppsala Monitoring Centre

Publisher

Springer Science and Business Media LLC

Reference34 articles.

1. Council for International Organizations of Medical Sciences. Glossary of ICH terms and definitions. Compiled by CIOMS from the International Council for Harmonization (ICH)’s Quality Safety Efficacy Miscellaneous Guidelines. Version 3. 20 April 2023. Available from: https://cioms.ch/publications/product/glossary-of-ich-terms-and-definitions. Accessed 20 Jun 2023.

2. European Medicines Agency. Inclusion/exclusion criteria for the “Important Medical Events” list. 2021. https://www.ema.europa.eu/en/documents/other/inclusion-exclusion-criteria-important-medical-events-list-meddra_en.pdf. Accessed 1 Jan 2023.

3. European Medicines Agency. Signal management—designated medical events. 2023. https://www.ema.europa.eu/en/human-regulatory/post-authorisation/pharmacovigilance/signal-management#designated-medical-events-section. Accessed 1 Jan 2023.

4. Onakpoya IJ, Heneghan CJ, Aronson JK. Delays in the post-marketing withdrawal of drugs to which deaths have been attributed: a systematic investigation and analysis. BMC Med. 2015;13(1):26. https://doi.org/10.1186/s12916-014-0262-7.

5. Sartori D, Aronson JK, Norén GN, Onakpoya IJ. Signals of adverse drug reactions communicated by pharmacovigilance stakeholders: a scoping review of the global literature. Drug Saf. 2023;46(2):109–20. https://doi.org/10.1007/s40264-022-01258-0.

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