Implications of Individual QT/RR Profiles—Part 2: Zero QTc/RR Correlations Do Not Prove QTc Correction Accuracy in Studies of QTc Changes
Author:
Funder
British Heart Foundation
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,Toxicology
Link
http://link.springer.com/article/10.1007/s40264-018-0735-2/fulltext.html
Reference13 articles.
1. Garnett CE, Zhu H, Malik M, Fossa AA, Zhang J, Badilini F, Li J, Darpö B, Sager P, Rodriguez I. Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects. Am Heart J. 2012;163:912–30.
2. Dang Q, Zhang J. Validation of QT interval correction methods when a drug changes heart rate. Ther Innov Regul Sci. 2013;47:256–60.
3. Malik M, Garnett C, Hnatkova K, Vicente J, Johannesen L, Stockbridge N. Implications of individual QT/RR profiles—part 1: inaccuracies and problems of population-specific QT/heart rate corrections. Drug Saf. 2018. https://doi.org/10.1007/s40264-018-0736-1 .
4. Hnatkova K, Smetana P, Toman O, Schmidt G, Malik M. Sex and race differences in QRS duration. Europace. 2016;18:1842–9.
5. Malik M, Hnatkova K, Kowalski D, Keirns JJ, van Gelderen EM. QT/RR curvatures in healthy subjects: sex differences and covariates. Am J Physiol Heart Circ Physiol. 2013;305:H1798–806.
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