Demonstration of a relatively hepatoselective effect of covalent insulin dimers on glucose metabolism in dogs

Author:

Shojaee-Moradie F.,Jackson N. C.,Boroujerdi M.,Brandenburg D.,S�nksen P. H.,Jones R. H.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference33 articles.

1. Prager R, Wallace P, Olefsky JM (1986) In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest 78: 472?481

2. Tompkins CV, Brandenburg D, Jones RH, Sönksen PH (1981) Mechanism of action of insulin and insulin analogues. Diabetologia 20: 94?101

3. Sönksen PH, Tompkins CV, Srivastava MC, Nabarro JDW (1973) A comparative study of human insulin and porcine proinsulin in man. Clin Sci Mol Med 45: 633?654

4. Lavelle-Jones M, Scott MH, Kolterman O et al. (1987) Selective suppression of hepatic glucose output by human proinsulin in the dog. Am J Physiol 252: E230-E236

5. Glauber H, Revers R, Henry R et al. (1986) In vivo deactivation of proinsulin action on glucose disposal and hepatic glucose production in normal man. Diabetes 35: 311?317

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