In Vitro Mechanisms of Lovastatin on Lung Cancer Cell Lines as a Potential Chemopreventive Agent

Author:

Maksimova Elena,Yie Ting-An,Rom William N.

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine

Reference39 articles.

1. Rom WN, Hay JG, Lee TC, Jiang Y, Tchou-Wong KM (2000) Molecular and genetic aspects of lung cancer. Am J Respir Crit Care Med 161:1355–1367

2. Mo H, Elson C (2004) Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. FASEB J 229:567–585

3. Bouterfa HL, Sattelmeyer V, Czub S, Vordermark D, Roosen K, Tonn JC (2000) Inhibition of Ras farnesylation by lovastatin leads to down-regulation of proliferation and migration in primary cultured human glioblastoma cells. Anticancer Res 20:2761–2771

4. Graham TE, Pfeiffer JR, Lee RJ, Kusewitt DF, Martinez AM, Foutz T, Wilson BS, Oliver JM (1998) MEK and ERK activation in ras-disabled RBL-2H3 mast cells and novel roles for geranylgeranylated and farnesylated proteins in Fc epsilonRI-mediated signaling. J Immunol 161:6733–6744

5. Tan A, Levrey H, Dahm C, Polunovsky VA, Rubins J, Bitterman PB (1999) Lovastatin induces fibroblast apoptosis in vitro and in vivo. Am J Respir Crit Care Med 159:220–227

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